What is the significance of the biomarker troponin T in ALS?

An increase in the biomarker troponin T (hs-cTnT), which is usually detectable in heart muscle damage
, was also identified in patients with ALS. This is seen as an indication of
damage to the skeletal muscles as part of the disease. Troponin T
thus potentially represents a biomarker for the degeneration of the second motor neuron.

Whether the level of troponin T correlates directly with the extent of degeneration of the second
motor neuron has not yet been conclusively determined. Initial studies suggest
that elevated levels may be associated with more rapid disease progression.
Further research is needed to better understand the exact pathophysiological significance and
potential use of troponin T as a prognostic or therapeutic biomarker in ALS
.