What is an ALS gene panel?

An ALS gene panel is a special genetic test that investigates the genetic causes of ALS.
Several genes associated with the disease
are analyzed simultaneously. The panel diagnosis includes frequently affected genes such as C9orf72, SOD1, TARDBP and
FUS, but also rare genes that are detectable in less than 1% of those affected,
including VCP, UBQLN2, OPTN and NEK1.

The aim of the test is to identify genetic mutations that are either the cause of ALS or increase the risk of ALS. The gene panel is particularly recommended for familial ALS, as the disease is often hereditary. The results help to assess individual risks and can be important in the planning of treatment strategies and in research into new therapies. A genetic test requires a blood or saliva sample and is carried out in specialized genetic laboratories.