General Terms and Conditions for Ambulanzpartner Soziotechnologie APST GmbH and for use of the APST platform and APST mobile applications.

Updated 25 November 2025

APST – Terms and Conditions (Version 2.4)

There is a strong need for medical research in neurological diseases, particularly amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and other neurodegenerative and neuromuscular disorders. Such research is essential for developing new therapies and improving health care in these conditions. A key advancement in modern medical science is the active involvement of patients through the structured collection of treatment data and the administration of therapy-related surveys. APST supports these research efforts by providing a digital research platform and mobile applications that digitally collect and manage research-related data for medical studies.

1. Scope

1.1. These General Terms and Conditions of Use (GTC) apply to the use of services provided by the Ambulanzpartner Soziotechnologie APST GmbH (hereinafter referred to as “APST”) and the use of the APST research platform (hereinafter referred to as “APST platform”) and mobile software applications, including the “ALS App”, “SMA App” and other mobile applications (hereinafter referred to as “APST apps”).

1.2. APST’s services support patients with chronic, severe or rare diseases in participating in medical research projects. Patients are authorised as app users and receive individual user accounts. The legal basis for this is provided by the individual agreements concluded at the time of the contract and by these General Terms and Conditions.

1.3. By registering, the patient (or legal representative) agrees to the General Terms and Conditions and the Privacy Policy. APST reserves the right to amend these General Terms and Conditions if necessary, in particular for factual and/or legal reasons, with reference to these reasons. The amended terms and conditions will be sent to the patient (or legal representative) by email one month before they come into effect to the email address last provided to APST and stored on the APST platform. If the patient has not objected within 14 days of receiving the email, the amended terms and conditions shall be deemed accepted and shall govern the future contractual relationship between the patient and APST. If the patient (or their legal representative) objects, the contract shall terminate in accordance with Section 4.2. 1.4. The patient may not transfer the rights and obligations arising from this contract. Any assignment of rights is excluded.

2. Subject matter of the contract and services

2.1. APST provides services that serve research, in particular research organisations and networking between patients, medical partners and scientific institutions. The entirety of these services is referred to as “research organisation” and includes the following components: • Coordination of the partners involved • Provision of the necessary participation documents (e.g., questionnaires) • Provision of technical requirements for data collection at home or in medical institutions (through APST apps or study software) • Conducting patient surveys via the APST apps, by telephone or by post • Coordination of the dispatch and analysis of biological samples The components of the research organisation can be used together or individually.

2.2. APST makes the APST platform available to patients for voluntary use. The APST platform is a structured database with an associated digital platform that enables the electronic collection, storage and processing of patient and research-related data as well as digital support for research processes. The APST platform and associated applications are software products of APST.

2.3. Access to APST apps is provided via a combination of a personal user name and password. These login details also enable patient authentication for APST apps. The functions of APST apps, the data collected, user roles and permissions, and the terms of use are outlined in the privacy policy.

2.4. APST provides patients with Apps that enable them to participate in surveys and evaluate disease symptoms, symptom progression, and treatment experience.

2.5. APST supports patients or their legal representatives and other users authorised by the patient in using Apps. APST offers a free telephone briefing before using Apps and, if necessary, further free, individually arranged training courses.

2.6. With the patient’s consent, their data is released to medical partners for viewing, processing and use. The patient is free to revoke their initial consent at any time with immediate effect without giving reasons. APST ensures that the corresponding declaration of consent meets all legal requirements, in particular data protection requirements.

2.7. The provision of the access requirements (e.g., internet connection and web browser) is not part of the contractual relationship between the patient and APST.

3. Conclusion of contract

3.1 The use of the services mentioned in 2.1 and the software of APST apps requires the conclusion of a user agreement. This contractual relationship is established by providing the patient with comprehensive information and by having the patient sign a consent form. For this purpose, the following documents will be sent or handed over to the patient: • APST’s privacy policy for research coordination and the use of APST apps and other study software for the purpose of data collection, evaluation, aggregation and analysis. • Declaration of consent to participate in research coordination and to use APST apps. The patient completes the necessary information (address, email address) on the consent form. By signing the consent form, the patient agrees to and accepts these GTC. The patient sends the signed consent form by post or email (with the signed document attached) to the following address: Ambulanzpartner Soziotechnologie APST GmbH Westhafenstr.1 13353 Berlin Germany or email: info@ambulanzpartner.de After receipt of the signed declaration of consent, the patient will receive an email with a registration link for the selected applications (“apps”). The patient assigns their own username and password.

3.2. By concluding the contract, the patient declares their agreement with these General Terms and Conditions and the privacy policy.

3.3. The patient warrants that the information provided by them when concluding the contract is complete and correct. In the event of a breach, APST is entitled to block the patient’s user account immediately.

4. Term and termination of the contract

4.1. The contractual relationship is concluded for an indefinite period.

4.2. Both parties may terminate the contract at any time with four weeks’ notice to the end of a month. Notice of termination must be given in writing or in text form. Ambulanzpartner Soziotechnologie APST GmbH Westhafenstr. 1 13353 Berlin or e-mail: info@ambulanzpartner.de

4.3 Both contracting parties are entitled to extraordinary termination for good cause, in particular in the event of a material breach of contract in which the continuation of the contract becomes unreasonable for one of the contracting parties.

4.4. The provisions of Section 2.5 and the resulting rights of the patient remain unaffected.

5. Patient obligations and security recommendations

5.1. The patient is obliged to keep their access data (user name, password) safe and, like valuables, protect it from unauthorised access by third parties. The patient is expressly recommended to use antivirus, antispyware, and firewall software, as well as the latest versions of their current browser. If the patient uses outdated browser versions, the APST apps may not display correctly. In this case, the patient can obtain information about suitable browsers and their versions from APST.

5.2. The patient undertakes not to post any illegal content on the APST app or make it accessible to third parties, for example, through forums, chat rooms, email or spam. Violations of the contractual restrictions on use entitle APST to take appropriate remedial measures, up to and including blocking the user account. In this case, the patient will be informed immediately of the type, duration, reason and scope of the block.

5.3. The accuracy of the data and information provided by the patient influences the value of the contractual services provided by APST. The patient expressly indemnifies APST against any claims for compensation by third parties who have relied on the completeness, accuracy and timeliness of the data and information.

6. Costs of using APST services and software

The use of APST apps is free of charge for patients and persons authorised by them.

7. Data security, consent to data processing, protection of patient data

7.1. APST is subject to the data protection regulations of the Federal Republic of Germany, the European Union (EU GDPR) and 235.1 Federal Act of 19 June 1992 on Data Protection (FADP). APST is obliged to protect the data of patients and other parties involved on the basis of these provisions.

7.2. APST takes all organisational and technical precautions required by current standards to meet data protection requirements, in particular to protect patient data against unauthorised access by third parties. The transfer of stored data via the World Wide Web from the server to the patient’s computer and vice versa is carried out using the SSL encryption standard.

7.3 The patient expressly declares their consent to the collection, processing and use of their data by APST within the scope of the contractually agreed purposes and by means of a separate data protection declaration.

8. Liability

8.1. APST shall be liable without limitation for all damages caused by APST and its legal representatives and/or vicarious agents in cases of intent or gross negligence.

8.2. In cases of slight negligence, APST shall be liable without limitation for any injury to life, limb or health caused by APST, its legal representatives and/or vicarious agents.

8.3. Liability under the Product Liability Act remains unaffected.

8.4. Otherwise, APST shall only be liable if a quality guarantee has been given or a material contractual obligation (cardinal obligation) has been breached. The term “cardinal obligation” refers abstractly to those obligations whose fulfilment is essential for the proper execution of the contract and on whose compliance the patient may regularly rely. In such cases, liability is limited to compensation for foreseeable, typically occurring damage.

9. Rights of use

9.1. APST grants the patient a simple (non-sublicensable and non-transferable) right of use, which is limited to the term of the contract.

9.2. The patient is only entitled to use the APST apps within the scope of the contractual provisions. The software is not transferred to the patient.

9.3. The patient is not entitled to make the contractual service available to third parties. Access for relatives of the patient or other persons authorised by the patient is excluded. With the patient’s consent, the third party authorised by the patient will receive an email from APST with a registration link for a selected APST app. This person will assign the username and password themselves. The patient is not permitted to sublet the contractual software.

10. Evaluations

10.1 APST provides patients and their authorized representatives with software tools, including APST apps and study-specific platforms, to record and evaluate the patient’s disease progression. The results of the evaluations are published in aggregated form, without naming the patient, on the APST homepage and its subpages. The patient agrees to the following regulations.

10.2. The evaluations must be objective and may not contain any illegal content. APST is not liable for the accuracy, quality or completeness of the assessments. APST will remove inappropriate or illegal evaluations if there is a clear indication.

11. Final provisions

11.1 Should any provision of these General Terms and Conditions be or become invalid or void, this shall not affect the validity of all other provisions. The invalid or void provision shall be replaced by a valid provision that comes as close as legally possible to the purpose pursued by the invalid or void provision. This also applies to any loopholes in these General Terms and Conditions.

11.2 The law of the Federal Republic of Germany shall apply. The statutory provisions restricting the choice of law and the applicability of mandatory provisions, in particular those of the country in which the patient as a consumer has his habitual residence, shall remain unaffected. If the patient is a merchant, a legal entity under public law or a special fund under public law, the registered office of APST shall be the exclusive place of jurisdiction for all disputes arising from the contractual relationship.